The role of hepatocellular derived exosomes in development of liver injuries in nonalcoholic fatty liver disease

ZHANG Qing; LIU Sutong; ZHAO Wenxia

doi:10.3969/j.issn.1671-038X.2023.08.15

Article navigation > Chin J Integr Tradit West Med Dig > 2023 > 31(8): 649-653

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ZHANG Qing, LIU Sutong, ZHAO Wenxia. The role of hepatocellular derived exosomes in development of liver injuries in nonalcoholic fatty liver disease[J]. Chin J Integr Tradit West Med Dig, 2023, 31(8): 649-653. doi: 10.3969/j.issn.1671-038X.2023.08.15

Citation:

The role of hepatocellular derived exosomes in development of liver injuries in nonalcoholic fatty liver disease

1.
Henan University of Traditional Chinese Medicine, Zhengzhou, 450046, China
2.
Department of Hepatology and Spleen-Stomach, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine

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Corresponding author: ZHAO Wenxia, E-mail: zhao_wenxia@163.com

Received Date: 19 December 2022

Publish Date: 15 August 2023

Abstract

Abstract

Exosomes are membranous vesicles secreted by a variety of cell types, and carry out the function of intercellular communication under normal and pathological conditions. More and more reports suggest that exosomes, especially hepatocellular derived exosomes, play an important role in the development of non-alcoholic steatohepatitis(NAFLD)/non-alcoholic steatohepatitis(NASH). In this review, we elucidate the mechanism of hepatogenic exosomes from the perspectives of liver injuries such as liver lipid metabolism, apoptosis, inflammation, and fibrosis, in order to provide reference for the study of NAFLD/NASH mechanism.
- non-alcoholic fatty liver disease /
- hepatocellular derived exosomes /
- lipid metabolism

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References

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