Therapeutic effect of Qingre Tongfu Huayu Formula combined with blood purification on acute pancreatitis

ZHOU Zhe; PING Liying; ZHENG Yang; XU Changqing

doi:10.3969/j.issn.1671-038X.2023.07.16

Article navigation > Chin J Integr Tradit West Med Dig > 2023 > 31(7): 567-572

Next Article Previous Article

ZHOU Zhe, PING Liying, ZHENG Yang, et al. Therapeutic effect of Qingre Tongfu Huayu Formula combined with blood purification on acute pancreatitis[J]. Chin J Integr Tradit West Med Dig, 2023, 31(7): 567-572. doi: 10.3969/j.issn.1671-038X.2023.07.16

Citation:

Therapeutic effect of Qingre Tongfu Huayu Formula combined with blood purification on acute pancreatitis

1.
Department of Emergency, the Third Hospital of Xingtai, Xingtai, Hebei, 054000, China
2.
Department of Nephrology, the Third Hospital of Xingtai
3.
Department of Gastroenterology, the Third Hospital of Xingtai

More Information

Corresponding author: XU Changqing, E-mail: 714023055@qq.com

Received Date: 12 February 2023

Publish Date: 15 July 2023

Abstract

Abstract

Objective
To investigate the efficacy of Qingre Tongfu Huayu Formula combined with blood purification in the treatment of acute pancreatitis, and its effects on intestinal microecology, gastric electroparameters, serum macrophage inflammatory protein-1α(MIP-1α) and E-cadherin.
Methods
One hundred and forty-eight patients with acute pancreatitis admitted from May 2020 to May 2022 were selected and divided into the observation group and the control group according to random number table method, with 74 cases in each group. The control group received conventional Western medicine treatment and blood purification, and the observation group received Qingre Tongfu Huayu Formula on the basis of the control group. The efficacy, Traditional Chinese Medicine syndrome score, intestinal microecology, electrogastrogram parameters and their effects on serum MIP-1α and E-cadherin were compared between the two treatments.
Results
The effective rate of the observation group was higher than that of the control group(91.89% vs 79.73%), the difference was statistically significant(P < 0.05). The improvement time of symptoms(abdominal pain, abdominal distension, intestinal sound) and laboratory indicators(blood image, blood amylase, urine amylase) in the observation group was shorter than that in the control group(P < 0.05). After treatment, the scores of the main syndroms(nausea and vomiting, epigastric pain, jaundice, fever, thin or smooth pulse, red tongue, and thin tongue) of the two groups were significantly decreased, and the scores of the observation group were lower than those of the control group(P < 0.05). After treatment, the levels of D-lactic acid, blood amylase, Enterobacterium, and Enterococcus were decreased in two groups, while the levels of bifidobacterium and Lactobacillus were increased, and the improvement degree of the observation group was better than the control group(P < 0.05). After treatment, FP, FZ and AP in the two groups showed an increasing trend, and the gastric electrical parameters in the observation group were higher than those in the control group(P < 0.05). Serum MIP-1α and E-cadherin in two groups were significantly decreased after treatment, and the levels of MIP-1α and E-cadherin in observation group were lower than those in the control group(P < 0.05).
Conclusion
Qingre Tongfu Huayu Formula combined with blood purification has a good effect in the treatment of acute pancreatitis, which can accelerate the recovery of symptoms, improve gastrointestinal physiological state and intestinal microecology, reduce the serum level of MIP-1α and E-cadherin, and has good safety, worthy of clinical promotion.
- hemodialysis /
- Qingre Tongfu Huayu Formula /
- acute pancreatitis /
- intestinal microecology /
- electrogastrogram /
- macrophage inflammatory protein-1α /
- E-cadherin

FullText(HTML)

References

[1]	Beyer G, Hoffmeister A, Lorenz P, et al. Clinical practice guideline, acute and chronic pancreatitis[J]. Dtsch Arztebl Int, 2022, 119(29-30): 495-501. Google Scholar
[2]	郭丹妮, 冯淑兰, 董明国. 电针配合大承气汤灌肠辅治重症急性胰腺炎胃肠功能障碍的临床观察[J]. 中国中西医结合消化杂志, 2022, 30(4): 275-279. Google Scholar
[3]	明志祥, 许健华, 张若怡. 加味清胰汤治疗急性胰腺炎的临床疗效分析[J]. 中国中西医结合消化杂志, 2021, 29(4): 284-287. Google Scholar
[4]	宋冰, 汪永锋, 张延英, 等. 中医辨证诊治急性胰腺炎方法研究[J]. 中华中医药学刊, 2020, 38(2): 88-91. Google Scholar
[5]	李君秋, 曹红燕, 肖铁刚, 等. 大承气汤治疗急性胰腺炎患者胃肠功能障碍的临床观察[J]. 中国中西医结合消化杂志, 2021, 29(10): 686-690. Google Scholar
[6]	杨丹, 魏莉莉, 孙银凤, 等. 中药灌肠联合西医常规疗法治疗重症急性胰腺炎临床疗效的Meta分析[J]. 中国中西医结合急救杂志, 2022, 29(2): 177-182. Google Scholar
[7]	焦巨英, 刘建均, 娄妮, 等. 中药调节急性胰腺炎肠道菌群紊乱[J]. 中华中医药学刊, 2020, 38(7): 135-138. Google Scholar
[8]	Garrido VT, Banerjee S. E-cadherin: an Enigma in pancreatic diseases[J]. Cell Mol Gastroenterol Hepatol, 2020, 9(1): 191-192. doi: 10.1016/j.jcmgh.2019.10.004 CrossRef Google Scholar
[9]	郭喆, 关键. 重症急性胰腺炎预防与阻断急诊专家共识[J]. 临床急诊杂志, 2022, 23(7): 451-462. Google Scholar
[10]	Wu XM, Ji KQ, Wang HY, et al. MIP-1α induces inflammatory responses by upregulating chemokine receptor 1/chemokine receptor 5 and activating c-Jun N-terminal kinase and mitogen-activated protein kinase signaling pathways in acute pancreatitis[J]. J Cell Biochem, 2019, 120(3): 2994-3000. doi: 10.1002/jcb.27049 CrossRef Google Scholar
[11]	王卫伟, 王忠玉. 腹腔镜联合胆道镜治疗急性胆源性胰腺炎伴胆囊结石疗效及对患者血清巨噬细胞炎性蛋白-1α、巨噬细胞炎性蛋白-1β和单核细胞趋化因子蛋白-1水平的影响[J]. 陕西医学杂志, 2021, 50(9): 1114-1118. Google Scholar
[12]	中华医学会消化病学分会胰腺疾病学组, 中华胰腺病杂志编辑委员会, 中华消化杂志编辑委员会. 中国急性胰腺炎诊治指南(2019年, 沈阳)[J]. 中华消化杂志, 2019, 39(11): 721-730. Google Scholar
[13]	张声生, 李乾构, 李慧臻, 等. 急性胰腺炎中医诊疗专家共识意见[J]. 中华中医药杂志, 2013, 28(6): 1826-1831. Google Scholar
[14]	郑筱萸. 中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社, 2002: 233-236. Google Scholar
[15]	Szatmary P, Grammatikopoulos T, Cai WH, et al. Acute pancreatitis: diagnosis and treatment[J]. Drugs, 2022, 82(12): 1251-1276. Google Scholar
[16]	钱家鸣, 吴东. 筚路蓝缕40年: 我国急性胰腺炎的基础和临床研究[J]. 中华消化杂志, 2021, 41(8): 505-508. Google Scholar
[17]	张继燃, 徐继扬. 急性胰腺炎肠黏膜上皮细胞凋亡及相关治疗的研究[J]. 临床急诊杂志, 2017, 18(7): 557-559. Google Scholar
[18]	申鼎成, 黄耿文. 危重型急性胰腺炎的研究进展[J]. 中国普通外科杂志, 2022, 31(9): 1129-1134. Google Scholar
[19]	Gliem N, Ammer-Herrmenau C, Ellenrieder V, et al. Management of severe acute pancreatitis: an update[J]. Digestion, 2021, 102(4): 503-507. Google Scholar
[20]	Iannuzzi JP, King JA, Leong JH, et al. Global incidence of acute pancreatitis is increasing over time: a systematic review and meta-analysis[J]. Gastroenterology, 2022, 162(1): 122-134. Google Scholar
[21]	刘凤斌, 胡玲, 陈苏宁, 等. 消化系统常见病急性胰腺炎中医诊疗指南(基层医生版)[J]. 中华中医药杂志, 2020, 35(4): 1906-1913. Google Scholar
[22]	王天麟, 冯彬彬, 韩俊泉, 等. 浅析"透热转气"及清营汤在重症急性胰腺炎继发脓毒症中的应用[J]. 中国中西医结合消化杂志, 2022, 30(12): 859-862, 866. Google Scholar
[23]	谢彩杏, 陈国忠, 陈小霞, 等. 基于国家专利数据库分析中药复方治疗急性胰腺炎用药规律[J]. 国际中医中药杂志, 2022, 44(7): 796-800. Google Scholar
[24]	Li XY, He C, Zhu Y, et al. Role of gut microbiota on intestinal barrier function in acute pancreatitis[J]. World J Gastroenterol, 2020, 26(18): 2187-2193. Google Scholar
[25]	Cienfuegos JA, Valenti V, Rotellar F. Acute pancreatitis: an opportunity for gastroenterology hospitalists?[J]. Rev Esp Enferm Dig, 2022, 114(2): 73-75. Google Scholar
[26]	宋曦, 徐奇, 何莲, 等. CPFA对重症急性胰腺炎患者炎性介质、肠黏膜屏障功能的影响[J]. 中国老年学杂志, 2022, 42(22): 5473-5475. Google Scholar
[27]	王晶晶, 蔡常春, 张晴, 等. 联合使用大黄、芒硝对重症急性胰腺炎患者肠道功能和炎性因子的影响[J]. 中成药, 2019, 41(5): 1191-1193. Google Scholar
[28]	张辉, 施仲义, 胡一迪, 等. 自拟通腑泻热汤联合中药保留灌肠法治疗重症急性胰腺炎的临床观察[J]. 中国中医急症, 2019, 28(2): 337-339. Google Scholar