ZHOU Zhe, PING Liying, ZHENG Yang, et al. Therapeutic effect of Qingre Tongfu Huayu Formula combined with blood purification on acute pancreatitis[J]. Chin J Integr Tradit West Med Dig, 2023, 31(7): 567-572. doi: 10.3969/j.issn.1671-038X.2023.07.16
Citation: ZHOU Zhe, PING Liying, ZHENG Yang, et al. Therapeutic effect of Qingre Tongfu Huayu Formula combined with blood purification on acute pancreatitis[J]. Chin J Integr Tradit West Med Dig, 2023, 31(7): 567-572. doi: 10.3969/j.issn.1671-038X.2023.07.16

Therapeutic effect of Qingre Tongfu Huayu Formula combined with blood purification on acute pancreatitis

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  • Objective

    To investigate the efficacy of Qingre Tongfu Huayu Formula combined with blood purification in the treatment of acute pancreatitis, and its effects on intestinal microecology, gastric electroparameters, serum macrophage inflammatory protein-1α(MIP-1α) and E-cadherin.

    Methods

    One hundred and forty-eight patients with acute pancreatitis admitted from May 2020 to May 2022 were selected and divided into the observation group and the control group according to random number table method, with 74 cases in each group. The control group received conventional Western medicine treatment and blood purification, and the observation group received Qingre Tongfu Huayu Formula on the basis of the control group. The efficacy, Traditional Chinese Medicine syndrome score, intestinal microecology, electrogastrogram parameters and their effects on serum MIP-1α and E-cadherin were compared between the two treatments.

    Results

    The effective rate of the observation group was higher than that of the control group(91.89% vs 79.73%), the difference was statistically significant(P < 0.05). The improvement time of symptoms(abdominal pain, abdominal distension, intestinal sound) and laboratory indicators(blood image, blood amylase, urine amylase) in the observation group was shorter than that in the control group(P < 0.05). After treatment, the scores of the main syndroms(nausea and vomiting, epigastric pain, jaundice, fever, thin or smooth pulse, red tongue, and thin tongue) of the two groups were significantly decreased, and the scores of the observation group were lower than those of the control group(P < 0.05). After treatment, the levels of D-lactic acid, blood amylase, Enterobacterium, and Enterococcus were decreased in two groups, while the levels of bifidobacterium and Lactobacillus were increased, and the improvement degree of the observation group was better than the control group(P < 0.05). After treatment, FP, FZ and AP in the two groups showed an increasing trend, and the gastric electrical parameters in the observation group were higher than those in the control group(P < 0.05). Serum MIP-1α and E-cadherin in two groups were significantly decreased after treatment, and the levels of MIP-1α and E-cadherin in observation group were lower than those in the control group(P < 0.05).

    Conclusion

    Qingre Tongfu Huayu Formula combined with blood purification has a good effect in the treatment of acute pancreatitis, which can accelerate the recovery of symptoms, improve gastrointestinal physiological state and intestinal microecology, reduce the serum level of MIP-1α and E-cadherin, and has good safety, worthy of clinical promotion.

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